Speaker Biography

Emina Panjeta

Wellingtonien Pharmacy, Germany

Title: Evaluation of serum lipid profile, Castelli risk index 1 and 2, nd AIP in association with glycated hemoglobin in Type 2 Diabetes Mellitus Patients

Emina Panjeta
Biography:

Abstract:

Introduction: UN Resolution of 2006 acknowledged diabetes as a global pandemic and infectious disease which made it an important medical and public health issue.At present, glycated hemoglobin(HbA1c) is widely accepted as a measure of glycemic control in established diabetes.Diabetic patients with elevated HbA1c values and dyslipidemia can be considered as a very high-risk group for cardiovascular disease (CVD).Therefore, the aim of this study was to analyze the lipid profile in serum of patients with diabetes mellitus type 2, and its relationship with HbA1c levels. Methods: The observational cross-sectional study included 60 diabetic patients, 30 men, and 30 women, age 32–94 years. Patients were assigned into two groups based on HbA1c values;Group 1:HbA1c ≤ 7% (good glycemic control) and Group 2:HbA1c > 7% (poor glycemic control). We analyzed the concentra­tion of glucose, HbA1c, and lipid profile including total cholesterol levels, triglycerides(TAG), low-density lipoproteins(LDL), and high-density lipoproteins(HDL). Castelli risk index 1(TC/HDL-cholesterol),Castelli risk index 2(LDL/HDL-cholesterol), atherogenic index of plasma(AIP)(log [TAG/ HDL-cholesterol]),as well as the ratio of triglycerides (TAG) to HDL-cholesterol were calculated. Results:Results showed that patients with good glyce­mic control were significantly older compared to patients with poor glycemic control. (p = 0.023) Significantly lower values of glucose concentration, TAG and the ratio TAG/HDLc were obtained in the group of patients with good glycemic control. (p < 0.0005) Patients with good glycemic control had lower values of Castelli 1 and Castelli 2 index, and atherogenic index of plasma, compared to patients with poor glycemic control, but this difference was not significant. (p > 0.005).Our study revealed a sig­nificant positive correlation between HbA1c and triglyceride level (r = 0.375; p = 0.003) and HbA1c and ratio triglyceride/HDLc (r = 0.335; p = 0.009).

Conclusion:Our study showed a statistically significant positive correlation between HbA1c and TAG,as well as HbA1c and TAG/HDL-cholesterol ratio,indicat­ing that HbA1c is associated with dyslipidemia in patients with type 2 diabetes mellitus in addition to as glycemic control parameter